Search results for " contract"
showing 10 items of 1376 documents
Meritevolezza degli interessi
2021
La voce affronta l’evoluzione del criterio della meritevolezza degli interessi, indagandone la genesi e poi analizzandone le principali concezioni. Da questo esame emerge che la meritevolezza fonda un giudizio di impronta causale sul contratto, principalmente atipico ma anche, sotto certi aspetti, su quello tipico, che va distinto da quello di liceità. La meritevolezza dà infatti forma a una delle due anime del sindacato sulla causa del contratto: quello teso a riscontrare il fondamento del contratto sul terreno economico e sociale tramite una valutazione di natura tipologica sulla razionalità dello schema di composizione degli interessi e sulla consistenza e diffusione di questi ultimi; e …
Code Contracts ja ComTest-yksikkötestausgenerointi .NET-kielissä
2015
Opetuksen tehostamiseen suunnattu työkalu ComTest osaa luoda yksikkötestejä koodin kommentteihin kirjoitettujen ohjeiden perusteella. Sopimuspohjaisessa suunnittelussa olion metodeille asetetaan ehtoja, joiden on oltava voimassa ennen operaation suorittamista tai sen jälkeen. Tällaiset ehdot voidaan automaattisesti kirjoittaa osaksi koodin kommentteja. Code Contracts on laajennos .NET-kieliin, jonka avulla sopimuspohjainen suunnittelu saadaan osaksi sovelluskehitystä. Tutkimuksessa selvitetään, miten ComTest ja Code Contracts liittyvät toisiinsa. ComTest, a tool mainly directed to make teaching more efficient, is able to create Unit Tests based on directions written in the code comments. In…
Leveraging Partnerships with Logistics Service Providers in Humanitarian Supply Chains by Blockchain-based Smart Contracts
2019
As humanitarian organizations are struggling to reach an increasing number of beneficiaries, humanitarian-business partnerships, such as the use of logistics service providers (LSPs), promise to improve effectivity and efficiency of humanitarian assistance. Blockchain-based smart contracts which ensure automation, transparency, and efficiency promise to facilitate partnerships, particularly if trust is low. In this paper, blockchain-based smart contracts are critically examined for their application to humanitarian supply chains (HSCs). We identify various adoption barriers which we categorize into organizational, technological, and environmental. As the use of blockchain-based smart contra…
A note on best proximity point theory using proximal contractions
2018
In this paper, a reduction technique is used to show that some recent results on the existence of best proximity points for various classes of proximal contractions can be concluded from the corresponding results in fixed point theory.
Best proximity point theorems for proximal cyclic contractions
2017
The purpose of this article is to compute a global minimizer of the function $$x\longrightarrow d(x, Tx)$$ , where T is a proximal cyclic contraction in the framework of a best proximally complete space, thereby ensuring the existence of an optimal approximate solution, called a best proximity point, to the equation $$Tx=x$$ when T is not necessarily a self-mapping.
Implantation failure of endometrial origin: what is new?
2018
To review recent findings related to possible causes of recurrent implantation failure of endometrial origin in normal uterus.Recent evidences suggest that in apparently normal endometria, RIF may associate with molecular and functional changes in the uterus such as abnormal endometrial microbiota, including the presence of chronic endometritis, poor synchronization between the blastocyst and endometrium, and/or excessive uterine peristalsis. An altered endometrial microbiota detected by molecular techniques has been recently related to poorer embryo implantation, even in apparently normal endometria. The use of the endometrial receptivity analysis test to obtain an objective signature of e…
Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors
2016
Dopamine (DA) acts as gut motility modulator, via D1- and D2-like receptors, but its effective role is far from being clear. Since alterations of the dopaminergic system could lead to gastrointestinal dysfunctions, a characterization of the enteric dopaminergic system is mandatory. In this study, we investigated the role of DA and D1- and D2-like receptors in the contractility of the circular muscle of mouse distal colon by organ-bath technique. DA caused relaxation in carbachol-precontracted circular muscle strips, sensitive to domperidone, D2-like receptor antagonist, and mimicked by bromocriptine, D2-like receptor agonist. 7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benz…
Autophagy is induced by resistance exercise in young men, but unfolded protein response is induced regardless of age.
2017
AIM Autophagy and unfolded protein response (UPR) appear to be important for skeletal muscle homoeostasis and may be altered by exercise. Our aim was to investigate the effects of resistance exercise and training on indicators of UPR and autophagy in healthy untrained young men (n = 12, 27 ± 4 years) and older men (n = 8, 61 ± 6 years) as well as in resistance-trained individuals (n = 15, 25 ± 5 years). METHODS Indicators of autophagy and UPR were investigated from the muscle biopsies after a single resistance exercise bout and after 21 weeks of resistance training. RESULTS Lipidated LC3II as an indicator of autophagosome content increased at 48 hours post-resistance exercise (P < .05) and …
Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.
2018
Quantification of abnormal contractile motions of cardiac tissue has been a noteworthy challenge and significant limitation in assessing and classifying the drug-induced arrhythmias (i.e. Torsades de pointes). To overcome these challenges, researchers have taken advantage of computational image processing tools to measure contractile motion from cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs). However, the amplitude and frequency analysis of contractile motion waveforms doesn't produce sufficient information to objectively classify the degree of variations between two or more sets of cardiac contractile motions. In this paper, we generated contractile motion dat…
Are the Myokines the Mediators of Physical Activity-Induced Health Benefits?
2016
BACKGROUND: The concept of the muscle as a secretory organ, developed during the last decades, partially answers to the issue of how the crosstalk between skeletal muscle and distant tissues happens. The beneficial effects of exercise transcend the simple improved skeletal muscle functionality: systemic responses to exercise have been observed in distal organs like heart, kidney, brain and liver. Increasing data have accumulated regarding the synthesis, the kinetics of release and the biological roles of muscular cytokines, now called myokines. The most recent techniques have meaningfully improved the identification of the muscle cell secretome, but several issues regarding the extent of se…